<?xml version="1.0" encoding="UTF-8"?><lom xmlns="http://ltsc.ieee.org/xsd/LOM" xmlns:lomfr="http://www.lom-fr.fr/xsd/LOMFR" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://ltsc.ieee.org/xsd/LOM http://www.lom-fr.fr/xsd/lomfrv1.0/std/lomfr.xsd">
<general>
<identifier>
<catalog>Canal-U_Ocms</catalog>
<entry>10817</entry>
</identifier>
<title><string language="fre"><![CDATA[Cardiovascular Clinical Trialists (CVCT) Forum - Paris 2012 : Globalization of Diabetes trials: Epidemiology of diabetes in the Middle East and Asian countries]]></string></title>
<language>ENG</language>
<description>
<string language="fre"><![CDATA[Title : Globalization of Diabetes trials: Epidemiology of diabetes in the Middle East and Asian countries
Speaker: Mohamed SOBHY, Alexandria, EGY
Abstract : Diabetes is one of the major public health problems worldwide due to its chronic nature and severe complications; it’s projected to become one of the world’s main disablers and killers within the next twenty five years as the number of people with diabetes is increasing in every country.
The global epidemic of Diabetes Mellitus disproportionately affects indigenous and developing populations. Most people with diabetes live in the economically less developed regions of the world in middle and low income countries with the greatest number of people with diabetes between 40 to 59 years of age and this may be due to lack of investment in the treatment of people with diabetes in low-income countries.This difference in diabetes expenditures may explain the high relative mortality rate between low and high income countries.
There are several etiological factors leading to this increase in the prevalence of diabetes, from the most important factors are: ethnicity-based differences, Obesity, Sedentary life style, childhood obesity as well as genetic Susceptibility. These factors are the main reasons that Africa, Middle East & Asia have the highest increasing percentage of diabetes between 2011 and 2030 as estimated from IDF Diabetes Atlas 2011.
According to IDF Diabetes Atlas 2011, the prevalence of Diabetes in Egypt is 15.2%, in Middle East 9.1% and in Asia 8.3%.
L’auteur n’a pas transmis de conflit d’intérêt concernant les données diffusées dans cette vidéo ou publiées dans la référence citée.
Conférence enregistrée : 9th Global Cardiovascular Clinical Trialists Forum • Paris 2012 
Diabetes clinical trials : helped or hindered by the current shift in regulatory requirements? Glycaemic control is an inadequate surrogate marker of cardiovascular event reduction in patients with type 2 diabetes. Clinical trials to date have been unsuccessful in identifying a therapeutic approach that addresses the underlying problem in diabetes (glycaemic control) and reduces cardiovascular risk. The potential for some agents to increase the risk of cardiovascular events has led to substantial changes in regulatory requirements for new anti-diabetic therapies. These requirements, while key to ensuring the cardiovascular safety of new agents, fail to emphasize the need to show clinical benefits, such as less visual impairment, less need for dialysis, or fewer cardiovascular events and deaths. Changes in test results such as glycaemic control, serum creatinine, micro-albuminuria, or retinopathy are inadequate surrogates. Regulators should consider the potential advantages of offering extended patent protection in order to encourage companies to conduct long-term trials in diabetes and many other chronic medical conditions. Cooperative efforts among physicians, clinical trialists, regulators, and sponsors are needed to address unresolved issues including re-defining therapeutic targets that are meaningful to patients with diabetes, determining the appropriate length of follow-up for future trials, and considering the ethical and operational challenges of non-inferiority designs.
Chairpersons: Marc PFEFFER, Boston, USA - Kausik RAY, London, GBR
Réalisation, production : Canal U/3S et CERIMES
Keyword : Cardiovascular Clinical Trialists, Paris, 2012, Cardiovascular prevention, Baro-stimulation, diabetes]]></string></description>
<keyword><string language="fre"><![CDATA[Cardiovascular Clinical Trialists, Paris, 2012, Cardiovascular prevention, Baro-stimulation, diabetes]]></string></keyword>
<lomfr:documentType>
<lomfr:source>LOMFRv1.0</lomfr:source>
<lomfr:value>image en mouvement</lomfr:value>
</lomfr:documentType>
</general><lifeCycle>
<contribute>
<role>
<source>LOMv1.0</source>
<value>author</value>
</role>
<entity><![CDATA[BEGIN:VCARD
VERSION:3.0
CLASS:PUBLIC
REV:2021-07-06 15:36:49
FN:Mohamed SOBHY
N:SOBHY;Mohamed;;;
URL;TYPE=work:https://www.canal-u.tv/auteurs/sobhy_mohamed
ROLE:author
NOTE:SOBHY Mohamed, Alexandria, EGY&lt;br&gt;Professor Sobhy is Immediate Past President of Egyptian Society of Cardiology and currently the Chairman of the Working Group of Cardiovascular Drug Therapy. He is a Fellow of both the American College of Cardiology and European Society of Cardiology (FACC and FESC, respectively). He is also a Fellow of the Emory University Hospital (USA), a Fellow of the Henry Ford Institute (USA), and a Fellow of the University of Lausanne, Switzerland. Professor Sobhy is a Board Member of the Working Group of Interventional Cardiology, and an active member of the Middle East Focus of the American College of Cardiology being the vice president in 2012, he is nominated as the Governor of Egypt chapter of American College of Cardiology ACC and of various advisory boards. 
TZ:+0200
END:VCARD
]]></entity>
<date><dateTime>2012-12-01</dateTime></date>
</contribute>
</lifeCycle>
<metaMetadata>
<metadataSchema>LOMv1.0</metadataSchema>
<metadataSchema>LOMFRv1.0</metadataSchema>
</metaMetadata>
<technical>
<format>video/mp4</format>
<location><![CDATA[https://www.canal-u.tv/video/canal_u_medecine/cardiovascular_clinical_trialists_cvct_forum_paris_2012_globalization_of_diabetes_trials_epidemiology_of_diabetes_in_the_middle_east_and_asian_countries.10817]]></location>
<location><![CDATA[https://streaming-canal-u.fmsh.fr/vod/media/canalu/videos/cutms/globalization.of.diabetes.trials.epidemiology.of.diabetes.in.the.middle.east.and.asian.countries_10817/1.02.cvct2012_sobhy_sd.mp4]]></location>
<location><![CDATA[https://streaming-canal-u.fmsh.fr/vod/media/canalu/videos/cutms/globalization.of.diabetes.trials.epidemiology.of.diabetes.in.the.middle.east.and.asian.countries_10817/1.02.cvct2012_sobhy_bd.mp4]]></location>
<size>60363258</size>
<duration><duration>PT0H11M50S</duration></duration>
</technical>
<educational>
<learningResourceType>
<source>LOMv1.0</source>
<value>lecture</value>
</learningResourceType>
<context>
<source>LOMv1.0</source>
<value>higher education</value>
</context>
<context>
<source>LOMv1.0</source>
<value>formation continue</value>
</context>
</educational>
<rights>
<cost>
<source>LOMv1.0</source>
<value>no</value>
</cost>
<copyrightAndOtherRestrictions>
<source>LOMv1.0</source>
<value>no</value>
</copyrightAndOtherRestrictions>
<description>
<string language="fre"><![CDATA[Droits réservés à l'éditeur et aux auteurs. 
]]></string>
</description>
</rights>
<relation>
<kind>
<source>LOMv1.0</source>
<value>ispartof</value>
</kind>
<resource>
<identifier>
<catalog>URI</catalog>
<entry>https://www.canal-u.tv/producteurs/canal_u_medecine/cardiologie/colloque_et_evenement/cvct</entry>
</identifier>
<description>
<string language="fre"><![CDATA[CVCT 9th Global Cardiovascular Clinical Trialists Forum • Paris 2012]]></string>
</description>
</resource>
</relation>
<classification>
<purpose>
<source>LOMv1.0</source>
<value>discipline</value>
</purpose>
<taxonPath>
<source>
<string language="fre"><![CDATA[Universités Numériques Thématiques 2009 http://www.universites-numeriques.fr]]></string>
</source>
<taxon>
<id/>
<entry>
<string language="fre"/>
</entry>
</taxon>
</taxonPath>
</classification>
<classification>
<purpose>
<source>LOMv1.0</source>
<value>discipline</value>
</purpose>
<taxonPath>
<source>
<string language="fre">CDD 22e éd.</string>
<string language="eng">DDC 22nd ed.</string>
</source>
<taxon>
<id>610</id>
<entry>
<string language="fre"><![CDATA[Sciences médicales. Médecine]]></string>
</entry>
</taxon>
</taxonPath>
</classification> </lom>