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<title><string language="fre"><![CDATA[Cardiovascular Clinical Trialists (CVCT) Forum – Paris 2012 : Impact of major clinical trials on ESC Chronic Heart Failure 2012 guidelines. Game changer trials: EMPHASIS-HF, SHIFT, Devices…]]></string></title>
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<string language="fre"><![CDATA[Title : Cardiovascular Clinical Trialists (CVCT) Forum – Paris 2012 : Impact of major clinical trials on ESC Chronic Heart Failure 2012 guidelines. Game changer trials: EMPHASIS-HF, SHIFT, Devices…
Speaker: Faiez ZANNAD, Nancy, FR
Discussant: John CLELAND, Hull, GBR
Abstract : Impact of major clinical trials on ESC Chronic Heart Failure 2012 guidelines. Game changer trials: EMPHASIS-HF, SHIFT, Devices…
L’auteur n’a pas transmis de conflit d’intérêt concernant les données diffusées dans cette vidéo ou publiées dans la référence citée.
9th Global Cardiovascular Clinical Trialists Forum • Paris 2012 
Multidisciplinary expert workshop : achievements challenges and barriers to implantation of the ESC 2012 chronic heart failure guidelines.
Chairpersons: Alain COHEN-SOLAL, Paris, FRA - Adrian VOORS, Groningen, NED
Background: The ESC-HFA chronic and acute heart failure guidelines have recently been published. However, the challenge for guidelines does not cease with a consensus document. Practical implementation is the critical step in establishing higher standards of care for individual patients. Improved guideline uptake is not only an index of better standards but a validation of the process of guideline production.
Improving consensus between guidelines is also important, differences in recommendations may act as a barrier to guideline. The NICE CHF guidance was updated in 2010, and it is not likely to be revised in short term.
Practice differs from the guideline recommendations. Registries suggest differences in guideline interpretation and treatment/management of CHF between different stakeholders. Similarities and differences exist between GPs and hospital physicians’ approaches to management of CHF. One important issue that is not covered by the current guidelines is the class effect issue. Canadian and Australian CHF guideline and 2010 NICE guideline name eplerenone as preferred drug in heart failure, ESC mentions only mineralocorticoid receptor antagonists (MRAs.) as a class.
How to interpret compound vs. class effects while following guideline recommendations is an important issue.
Cost-effectiveness is a key not only to the content of guidelines but also in the assessment of implementation. Limits on healthcare resources mandate that resource-allocation decisions be guided by considerations of cost in relation to expected benefits. In cost-effectiveness analysis, the ratio of net healthcare costs to net health benefits provides an index by which priorities may be set.
Aims: This multidisciplinary consensus workshop aims at discussing CHF guideline implementation issues and the consequences on defining the place of MRA/eplerenone in management of CHF.
Réalisation, production : Canal U/3S et CERIMES
Keyword : Cardiovascular Clinical Trialists, Paris, 2012, Cardiovascular prevention, ESC-HFA, eplerenone]]></string></description>
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NOTE:ZANNAD Faiez, Nancy, FRA&lt;br&gt;Faiez Zannad, MD, PhD is Professor of Therapeutics at the Medical Faculty of the Henri Poincaré University of Nancy. He obtained his MD as a Cardiology specialist in 1979 from the Faculté de Médecine de Nancy. In 1981 he served as a Research Fellow at the Clinical Pharmacology Medical Research Unit of Oxford University, UK and in 1986 he obtained his PhD in cardiovascular clinical pharmacology at the University of Lyon. He is currently Head of the Division of Heart Failure, Hypertension and Preventive Cardiology/ department of Cardiovascular Disease of the academic hospital of Nancy, and Director of the Clinical Investigation Center (CIC), mutually funded by the academic hospital and the INSERM and of a research group at an INSERM Unit (U961, Cardiac Fibrosis, Stiffness and cardiovascular risk) at the Faculté de Médecine. He is national coordinator of the network of 15 Clinical Investigation Centres working in the cardiovascular field in France. He is coordinating a Joint Research Program on transition from Hypertension to Heart Failure, in the 6th FP EU funded Network Excellence “InGeniousHyperCare”. He conducts his research, in the area of physiopathology and pharmacotherapeutics of hypertension and heart failure. Dr Zannad is Past Chairman of the Board of the French Society of Hypertension, Fellow of the European Society of Cardiology (ESC), Chairman of the ESC Working group on pharmacology and drug therapy as well as Board member of the ESC Heart Failure Association. He is currently Co- Editor in chief of Fundamental and Clinical Pharmacology, the official journal of the European Federation of Pharmacological Societies (EPHAR) and a member of the Editorial boards of a number of journals in the field of Cardiology, Hypertension and Cardiovascular Pharmacology.&nbsp; He has contributed more than 300 scientific publications and published several books on cardiovascular pharmacotherapy and on Heart Failure. He is chairman and organizer of several international meetings: “CardioVascular Clinical Trialists (CVCT) Forum and Workshop” (Cannes and Paris, with Bertram Pitt and Desmond Julian); “Acute Heart Failure Syndromes” (Cannes and Chicago, with Mihai Gheoghiade) and “Biomarkers in Heart Failure” (Cannes, with Kirkwood Adams). Dr. Zannad is involved in a number of major cardiovascular clinical trials, as a Principal Investigator and/or as a chair or member of several Steering Committees, Critical Event Committees and Data Safety and Monitoring Boards. : Executive Steering committee member: CIBIS 11, RALES VALIANT, RECOVER, MOXCON, EPHESUS,, EVEREST, AURORA, EXAMINE, ASTRONAUT, AXIOM-ACS, SERVEHF, HF-ACTION; NECTAR-HF, PEARL-HF, ALBATROSS, REMINDRE, FOSIDIAL (Chairman), EMPHASIS-HF (Chairman) Steering Committee membership: APSI, FIRST, CIBIS I, ASCEND-HF, CAPRICORN, Critical Event Committee: CAPRICORN, RESPECT, SCOUT, EchoCRT 
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