<?xml version="1.0" encoding="UTF-8"?><lom xmlns="http://ltsc.ieee.org/xsd/LOM" xmlns:lomfr="http://www.lom-fr.fr/xsd/LOMFR" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://ltsc.ieee.org/xsd/LOM http://www.lom-fr.fr/xsd/lomfrv1.0/std/lomfr.xsd">
<general>
<identifier>
<catalog>Canal-U_Ocms</catalog>
<entry>11439</entry>
</identifier>
<title><string language="fre"><![CDATA[Cardiovascular Clinical Trialists (CVCT) Forum – Paris 2012 - Debate Session 5 : The Vaptans story post-EVEREST (Michael FELKER)]]></string></title>
<language>ENG</language>
<description>
<string language="fre"><![CDATA[MODIGLIANI Debate Session 5 - Saturday December 1st, 2012
NOVEL DIURETIC STRATEGIES IN HEART FAILURE
Chairpersons: Keld KJELDSEN, Copenhagen, DEN - Gian Paolo ROSSI, Padua, ITA
Webcast: Patrick ROSSIGNOL, Nancy, FRA
? Clinical congestion due to volume overload is the main cause of hospitalization for patients with HF and is an important therapeutic target. Failure to achieve effective and rapid correction of this condition in many patients hospitalized for HF results in prolongation of hospital stay and unfavorable after-discharge outcome.
? Loop diuretics, though often effective for treating congestion, have significant limitations. Discovering ways to optimize exposure to loop diuretics, achieving effective decongestion while protecting renal function, is an important goal of current clinical research in HF.
? Vasopressin antagonists are effective in removing large amounts of water, but not salt, in HF. The EVEREST trial in unselected acute systolic heart failure did not show benefit on CV outcomes and only a modest benefit on dyspnea. Whether vaptans in HF are still a viable option is an important question. Better targeting specific vasopressin receptors with highly selective agents, better profiling of patients more likely to benefit, combination with mineralocorticoid receptor antagonists are options that are worth exploring.
? Aquapharesis (Ultrafiltration: UF) has been shown to be a safe and effective therapeutic modality for correction of volume overload in hospitalized patients with HF, not responding to intravenous diuretics and vasoactive medications. Should UF replace intravenous diuretics as a first-line therapy for patients with hypervolemia admitted for HF? The validity of such a concept is being examined in the NHLBI larger CARRESS study.
Session program:
Insights from DOSE and gaps in evidence with diuretic therapy
Speaker: Alice MASCETTE, NHLBI, USA
The Vaptans story post-EVEREST.
What is next? ACTIVATE, TACTICS and BALANCE trials
Speaker: Michael FELKER, Durham, USA
Discussant: William T. ABRAHAM, Colombus, USA
Ultrafiltration for acute cardiorenal syndrome in heart failure. UNLOAD and AVOID-HF and CARRESS trial
Speaker: Gian Paolo ROSSI, Padua, ITA
Debate: New diuretic modalities: Remaining gaps in evidence or ready for clinical use?]]></string></description>
<keyword><string language="fre"><![CDATA[Maladies cardiovasculaires]]></string></keyword>
<lomfr:documentType>
<lomfr:source>LOMFRv1.0</lomfr:source>
<lomfr:value>image en mouvement</lomfr:value>
</lomfr:documentType>
</general><lifeCycle>
<contribute>
<role>
<source>LOMv1.0</source>
<value>content provider</value>
</role>
<entity><![CDATA[BEGIN:VCARD
VERSION:3.0
CLASS:PUBLIC
REV:2021-07-06 15:41:40
FN:Canal U/3S - CERIMES
N:Canal U/3S - CERIMES;;;;
URL;TYPE=work:https://www.canal-u.tv/auteurs/canal_u_3s_cerimes
ROLE:content provider
TZ:+0200
END:VCARD
]]></entity>
<date><dateTime>2012-12-01</dateTime></date>
</contribute>
<contribute>
<role>
<source>LOMv1.0</source>
<value>publisher</value>
</role>
<entity><![CDATA[BEGIN:VCARD
VERSION:3.0
CLASS:PUBLIC
REV:2021-07-06 15:41:40
FN:Canal U/3S - CERIMES
N:Canal U/3S - CERIMES;;;;
URL;TYPE=work:https://www.canal-u.tv/auteurs/canal_u_3s_cerimes
ROLE:publisher
TZ:+0200
END:VCARD
]]></entity>
<date><dateTime>2012-12-01</dateTime></date>
</contribute>
<contribute>
<role>
<source>LOMv1.0</source>
<value>author</value>
</role>
<entity><![CDATA[BEGIN:VCARD
VERSION:3.0
CLASS:PUBLIC
REV:2021-07-06 15:41:40
FN:Michael FELKER
N:FELKER;Michael;;;
URL;TYPE=work:https://www.canal-u.tv/auteurs/felker_michael
ROLE:author
NOTE:FELKER Michael, Durham, USA G. Michael Felker, MD, MHS, is an Associate Professor in the Division of Cardiology at Duke University Medical Center and the Director of Heart Failure Research at the Duke Clinical Research Institute. He did his medical training at Duke University School of Medicine, his internal medicine training at Johns Hopkins Hospital where he was chief resident, and his cardiology training at Duke. Dr. Felker has published over 120 peer reviewed articles and book chapters in the field of heart failure. He has served on the Steering Committee for multiple national and international clinical trials in heart failure. He Directs the Advanced Heart Failure Fellowship Training Program at the Duke University School of Medicine. Dr Felker is an editorial board member or peer reviewer for multiple high impact medical journals, including the New England Journal of Medicine, JAMA, Lancet, Circulation, and JACC. He is the Associate Editor of JACC: Heart Failure and co-editor of Heart Failure: A Companion to Braunwald’s Heart Disease textbook. His research focus in on clinical trials (including clinical trials methodology) in acute and chronic heart failure, and the use of biomarkers as diagnostics, prognostic, and therapeutic tools in heart failure. 
TZ:+0200
END:VCARD
]]></entity>
<date><dateTime>2012-12-01</dateTime></date>
</contribute>
</lifeCycle>
<metaMetadata>
<metadataSchema>LOMv1.0</metadataSchema>
<metadataSchema>LOMFRv1.0</metadataSchema>
</metaMetadata>
<technical>
<format>video/mp4</format>
<location><![CDATA[https://www.canal-u.tv/video/canal_u_medecine/cardiovascular_clinical_trialists_cvct_forum_paris_2012_debate_session_5_the_vaptans_story_post_everest_michael_felker.11439]]></location>
<location><![CDATA[https://streaming-canal-u.fmsh.fr/vod/media/canalu/videos/cutms/cardiovascular.clinical.trialists.cvct.forum.a.paris.2012.debate.session.5.the.vaptans.story.post.everest.william.t.abraham.copie._11439/modigliani_debatesession5_michaelfelker_std.mp4]]></location>
<location><![CDATA[https://streaming-canal-u.fmsh.fr/vod/media/canalu/videos/cutms/cardiovascular.clinical.trialists.cvct.forum.a.paris.2012.debate.session.5.the.vaptans.story.post.everest.william.t.abraham.copie._11439/modigliani_debatesession5_michaelfelker_bd.mp4]]></location><location><![CDATA[https://streaming-canal-u.fmsh.fr/vod/media/canalu/videos/cutms/cardiovascular.clinical.trialists.cvct.forum.a.paris.2012.debate.session.5.the.vaptans.story.post.everest.william.t.abraham.copie._11439/modigliani_debatesession5_michaelfelker_hd.mp4]]></location>
<size>48761256</size>
<duration><duration>PT0H12M13S</duration></duration>
</technical>
<educational>
<learningResourceType>
<source>LOMv1.0</source>
<value>lecture</value>
</learningResourceType>
<context>
<source>LOMv1.0</source>
<value>higher education</value>
</context>
<context>
<source>LOMv1.0</source>
<value>formation continue</value>
</context>
</educational>
<rights>
<cost>
<source>LOMv1.0</source>
<value>no</value>
</cost>
<copyrightAndOtherRestrictions>
<source>LOMv1.0</source>
<value>no</value>
</copyrightAndOtherRestrictions>
<description>
<string language="fre"><![CDATA[Droits réservés à l'éditeur et aux auteurs. 
]]></string>
</description>
</rights>
<relation>
<kind>
<source>LOMv1.0</source>
<value>ispartof</value>
</kind>
<resource>
<identifier>
<catalog>URI</catalog>
<entry>https://www.canal-u.tv/producteurs/canal_u_medecine/cardiologie/colloque_et_evenement/cvct</entry>
</identifier>
<description>
<string language="fre"><![CDATA[CVCT 9th Global Cardiovascular Clinical Trialists Forum • Paris 2012]]></string>
</description>
</resource>
</relation>
<classification>
<purpose>
<source>LOMv1.0</source>
<value>discipline</value>
</purpose>
<taxonPath>
<source>
<string language="fre"><![CDATA[Universités Numériques Thématiques 2009 http://www.universites-numeriques.fr]]></string>
</source>
<taxon>
<id/>
<entry>
<string language="fre"/>
</entry>
</taxon>
</taxonPath>
</classification>
<classification>
<purpose>
<source>LOMv1.0</source>
<value>discipline</value>
</purpose>
<taxonPath>
<source>
<string language="fre">CDD 22e éd.</string>
<string language="eng">DDC 22nd ed.</string>
</source>
<taxon>
<id>616.1</id>
<entry>
<string language="fre"><![CDATA[Maladies de l'appareil cardio-vasculaire]]></string>
</entry>
</taxon>
</taxonPath>
</classification> </lom>