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<title><string language="fre"><![CDATA[Prof. Mike Surette - The Good and the Bad of Commensal-Pathogen Interactions in the Airways]]></string></title>
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<string language="fre"><![CDATA[The airways are
colonized by a complex microbiota that varies in composition and density spatially
throughout the respiratory tract, as well as temporally through the life-course.
 While the lower respiratory tract has
traditionally been considered sterile in healthy individuals, it is now clear
that the lower airways are continuously seeded with microbiota from oral and
upper respiratory tract. This may represent a transient community that is
cleared and reseeded in healthy individuals; however, it is clear that in
chronic airway disease, members of this commensal microbiota thrive in the
lower airways.  Here they are often in
the presence of the pathogens traditionally associated with chronic lung
infections.  These may simply represent
opportunistic colonizers with little contribution to disease, or they may
contribute to disease as part of polymicrobial infections, or more directly as
pathogens themselves.  The pathogenic
potential of many commensal microbiota is under appreciated.  Conversely, the commensal microbiota plays an
integral role in colonization resistance, and the ability of commensal
microbiota to inhibit the growth of common pathogens is widespread.  The dichotomy in ‘good vs bad’ behaviour of
commensal microbiota is often a ‘strain’ rather than species specific
property.  While the complexity of these
commensal-pathogen Interactions pose a challenge in standard diagnostic and
microbiome profiling approaches to respiratory disease, they do represent opportunities
for novel interventions in managing chronic airway disease and reducing
susceptibility to respiratory infections in vulnerable populations.
 ]]></string></description>
<keyword><string language="fre"><![CDATA[pathologie des poumons]]></string></keyword><keyword><string language="fre"><![CDATA[microbiota]]></string></keyword>
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<date><dateTime>2020-09-25</dateTime></date>
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<string language="fre"><![CDATA[Droits réservés à l'éditeur et aux auteurs. 
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<string language="fre"><![CDATA[LE STUDIUM Conferences]]></string>
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<description>
<string language="fre"><![CDATA[Novel host- and microbiota-directed strategies for treating respiratory infections]]></string>
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<string language="fre"><![CDATA[Universités Numériques Thématiques 2009 http://www.universites-numeriques.fr]]></string>
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<string language="fre"><![CDATA[Maladies des poumons (hypertension artérielle pulmonaire, hypertension pulmonaire, maladie obstructive respiratoire chronique, maladies respiratoires, ouvrages généraux sur les maladies des bronches et des poumons)]]></string>
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