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<title><string language="fre"><![CDATA[Prof. Kingston Mills - Local T cells and their subversion in protective immunity to infection in the respiratory tract]]></string></title>
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<string language="fre"><![CDATA[Respiratory
infection with Bordetella pertussis causes
whooping cough. The infection is controlled by innate immune responses, but complete
bacterial clearance from the respiratory tract and protection against
re-infection is mediated largely by Th1 and Th17 cells. However the bacteria
has evolved sophisticated immune subversion strategies to subvert these
responses Antigen-specific
regulatory T (Treg) cells that secrete IL-10 are induced in the respiratory
tract during B. pertussis infection
and suppress protective T cell responses. Pertussis disease can be prevented in children
by immunization with acellular pertussis (aP) vaccines. However, aP vaccines
fail to prevent nasal colonization and transmission of B. pertussis and may enhance infection in the nasal mucosae. This
may be due to activation of immune checkpoints or Treg cells. aP vaccine fail
to induce Th1
or Th17 cells or  respiratory tissue
resident memory T (TRM) cells that maintain long term immunity in
the respiratory tract. We found that blocking IL-10 during immunization
restores the induction of Th1 and Th17 responses and enhances efficacy of an aP
vaccine. Furthermore, we have demonstrated that immunization with an aP vaccine
formulated with a novel adjuvant combination, comprising TLR2 and STING
agonists, induces Th1- and Th17-type TRM cells in the lung and nasal
tissue, especially when delivered by nasal route, and this confers long-term protection
against nasal colonization as well as lung infection.
 ]]></string></description>
<keyword><string language="fre"><![CDATA[immunité]]></string></keyword><keyword><string language="fre"><![CDATA[pathologie des poumons]]></string></keyword>
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<date><dateTime>2020-09-25</dateTime></date>
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<string language="fre"><![CDATA[LE STUDIUM Conferences]]></string>
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<string language="fre"><![CDATA[Novel host- and microbiota-directed strategies for treating respiratory infections]]></string>
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<string language="fre"><![CDATA[Maladies des poumons (hypertension artérielle pulmonaire, hypertension pulmonaire, maladie obstructive respiratoire chronique, maladies respiratoires, ouvrages généraux sur les maladies des bronches et des poumons)]]></string>
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