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<title><string language="fre"><![CDATA[Dr Nicolas Guyot - Phylogenetic and structural evolution of egg antimicrobial proteins and peptides]]></string></title>
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<string language="fre"><![CDATA[The avian egg is designed to support the autonomous
development of the chick embryo in the outside environment. It initially
contains all the nutrients required for embryonic growth and provides efficient
physical and immune protections primarily via the calcified eggshell and the
numerous antimicrobial proteins and peptides. The antimicrobial content of eggs
has been shaped during evolution to cope with the microbial pressure and
potential contaminations. These antimicrobials are present within all parts of
the egg, although they are mostly abundant and active in the egg white and in
the perivitelline layer. Egg antimicrobial molecules show high structural and
functional diversity, displaying bactericidal or bacteriostatic activities via
different but complementary mechanisms (e.g. interaction with bacterial cells
which further triggers permeabilization and bacterial death, decrease in the
bioavailability of nutrients required for microbial growth, inhibition of
microbial proteases involved in virulence). Interestingly, some of these
antimicrobials lack orthologs in mammals and are specifically deposited in eggs
by the hen during egg formation, which suggests that they have a specific role
in the innate immune protection of the avian egg, or even other biological
functions related to avian reproduction. The presentation will mainly focus on
a selected panel of relevant egg antimicrobial proteins and peptides with a
particular emphasis on their structural and phylogenetic features.]]></string></description>
<keyword><string language="fre"><![CDATA[coquille oeuf]]></string></keyword>
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<date><dateTime>2021-03-23</dateTime></date>
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<string language="fre"><![CDATA[Droits réservés à l'éditeur et aux auteurs. 
@ LE STUDIUM 2021]]></string>
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<description>
<string language="fre"><![CDATA[Innate immunity in a biomineralized context: trade-offs or synergies?]]></string>
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