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<title><string language="fre"><![CDATA[Dr Jeba Jesudoss Chelladurai - P-glycoproteins of Toxocara canis: characterization of expression and pharmacological activity]]></string></title>
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<string language="fre"><![CDATA[The interaction of the macrocyclic lactones
with P-glycoprotein have been well-characterized in different ascarids and have
been implicated in drug resistance. While adult stages of the canine ascarid Toxocara
canis do not exhibit resistance, somatic larvae have been tolerant of the
macrocyclic lactones, except when used at very high concentrations. The role of
drug efflux proteins this tolerance phenomenon is not completely understood. We
demonstrate the expression of P-gp pumps in hatched and mouse liver-derived T.
canis larvae, and explored the interaction of hatched larvae with P-gp
fluorescent substrate in the presence and absence of P-gp inhibitors. We
further cloned and characterized the pharmacology of Tca-Pgp-11. Taken together,
our data demonstrates that T. canis P-gps could represent exploitable
targets in the control of this canine ascarid.
 ]]></string></description>
<keyword><string language="fre"><![CDATA[toxoplasmose]]></string></keyword>
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<date><dateTime>2021-11-29</dateTime></date>
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<description>
<string language="fre"><![CDATA[Droits réservés à l'éditeur et aux auteurs. 
]]></string>
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<string language="fre"><![CDATA[LE STUDIUM Conferences]]></string>
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<string language="fre"><![CDATA[New approaches to get around roundworms]]></string>
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<string language="eng">DDC 22nd ed.</string>
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<string language="fre"><![CDATA[Sciences de la vie. Biologie]]></string>
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