Ressource pédagogique : Cardiovascular Clinical Trialists (CVCT) Forum – RAAS inhibitors and Mineralocorticoid receptor antagonists (FOSIDIAL, ALCHEMIST)

cours / présentation - Date de création : 01-12-2012
Auteur(s) : Patrick ROSSIGNOL
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Présentation de: Cardiovascular Clinical Trialists (CVCT) Forum – RAAS inhibitors and Mineralocorticoid receptor antagonists (FOSIDIAL, ALCHEMIST)

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Langue du document : Anglais
Type pédagogique : cours / présentation
Niveau : enseignement supérieur, formation continue
Durée d'exécution : 22 minutes 32 secondes
Contenu : image en mouvement
Document : video/mp4
Taille : 109.46 Mo
Droits d'auteur : libre de droits, gratuit
Droits réservés à l'éditeur et aux auteurs.

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Title : Cardiovascular Clinical Trialists (CVCT) Forum – RAAS inhibitors and Mineralocorticoid receptor antagonists (FOSIDIAL, ALCHEMIST) Speaker: Patrick ROSSIGNOL, Nancy, FRA Abstract : RAAS inhibitors and Mineralocorticoid receptor antagonists (FOSIDIAL, ALCHEMIST) L’auteur n’a pas transmis de conflit d’intérêt concernant les données diffusées dans cette vidéo ou publiées dans la référence citée. Conférence enregistrée : 9th Global Cardiovascular Clinical Trialists Forum • Paris 2012 Cardiovascular prevention in chronic kidney disease. New therapeutic options and future opportunities - Cardiovascular events are 10 to 20 fold higher in CKD patients. Heart failure is the main cardiovascular complication that occurs in renal patients. Nearly all CV prevention and heart failure trials excluded patients with moderate to severe CKD. Therefore, the general approach and recommendations for CV prevention in the general population may not be equally effective and completely safe in renal patients. - Renal failure is associated with increased vascular inflammation and oxidative stress linked to development of cardiovascular disease. Nrf-2 (NF-E2-related factor 2) is a regulator of anti-oxidant, anti-inflammatory and detoxification pathways. Intervention trials of the synthetic nrf2/nf?b modulator, bardoloxone methyl, in patients with advanced kidney disease associated with type 2 diabetes, demonstrated improvement of renal function (BEAM trial), suggesting that such agents may have therapeutic benefit in chronic renal failure. - The ongoing BEACON trial assesses the efficacy of bardoxolone methyl relative to placebo in delaying progression to end-stage renal disease and cardiovascular deaths in patients with Stage 4 CKD and type 2 diabetes. - More specifically in chronic hemodialysis patients, results from the very few clinical trials undertaken thus far, including trials on lipid reduction, normalization of hematocrit, and increased dialysis dosage, have been unsuccessful. - New CV prevention opportunities are being investigated in specific trials in CKD and hemodialysis patients. The aim of this workshop is to discuss innovative designs and execution plans of CV prevention trials in CKD as well as the interpretation and implementation of the results of such trials and the approvability - regitrsbaility of potentially new CV prevention in CKD indications. Chairpersons: David GOLDSMITH, London, GBR - Luis RUILOPE, Madrid, ESP Réalisation, production : Canal U/3S et CERIMES Keyword : Cardiovascular Clinical Trialists, Paris, 2012, Cardiovascular prevention, Baro-stimulation

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  • Sciences médicales. Médecine (610)

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Document(s) annexe(s) - Cardiovascular Clinical Trialists (CVCT) Forum – RAAS inhibitors and Mineralocorticoid receptor antagonists (FOSIDIAL, ALCHEMIST)

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AUTEUR(S)

  • Patrick ROSSIGNOL

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  • Identifiant de la fiche
    10884
  • Identifiant
    oai:canal-u.fr:10884
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  • Entrepôt d'origine
    Canal-U