Ressource pédagogique : Dr Jeba Jesudoss Chelladurai - P-glycoproteins of Toxocara canis: characterization of expression and pharmacological activity

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The interaction of the macrocyclic lactones with P-glycoprotein have been well-characterized in different ascarids and have been implicated in drug resistance. While adult stages of the canine ascarid Toxocara canis do not exhibit resistance, somatic larvae have been tolerant of the macrocyclic lactones, except when used at very high concentrations. The role of drug efflux proteins this tolerance phenomenon is not completely understood. We demonstrate the expression of P-gp pumps in hatched and mouse liver-derived T. canis larvae, and explored the interaction of hatched larvae with P-gp fluorescent substrate in the presence and absence of P-gp inhibitors. We further cloned and characterized the pharmacology of Tca-Pgp-11. Taken together, our data demonstrates that T. canis P-gps could represent exploitable targets in the control of this canine ascarid.  

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• Sciences de la vie. Biologie (570)

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