Ressource pédagogique : Prof. Kingston Mills - Local T cells and their subversion in protective immunity to infection in the respiratory tract

Informations pratiques sur cette ressource

Description de la ressource pédagogique

Description (résumé)

Respiratory infection with Bordetella pertussis causes whooping cough. The infection is controlled by innate immune responses, but complete bacterial clearance from the respiratory tract and protection against re-infection is mediated largely by Th1 and Th17 cells. However the bacteria has evolved sophisticated immune subversion strategies to subvert these responses Antigen-specific regulatory T (Treg) cells that secrete IL-10 are induced in the respiratory tract during B. pertussis infection and suppress protective T cell responses. Pertussis disease can be prevented in children by immunization with acellular pertussis (aP) vaccines. However, aP vaccines fail to prevent nasal colonization and transmission of B. pertussis and may enhance infection in the nasal mucosae. This may be due to activation of immune checkpoints or Treg cells. aP vaccine fail to induce Th1 or Th17 cells or  respiratory tissue resident memory T (TRM) cells that maintain long term immunity in the respiratory tract. We found that blocking IL-10 during immunization restores the induction of Th1 and Th17 responses and enhances efficacy of an aP vaccine. Furthermore, we have demonstrated that immunization with an aP vaccine formulated with a novel adjuvant combination, comprising TLR2 and STING agonists, induces Th1- and Th17-type TRM cells in the lung and nasal tissue, especially when delivered by nasal route, and this confers long-term protection against nasal colonization as well as lung infection.  

"Domaine(s)" et indice(s) Dewey

• Maladies des poumons (hypertension artérielle pulmonaire, hypertension pulmonaire, maladie obstructive respiratoire chronique, maladies respiratoires, ouvrages généraux sur les maladies des bronches et des poumons) (616.24)

Thème(s)